Richie Barker made five changes to the side that beat Gillingham in the Johnstone's Paint Trophy on Tuesday night.
In came captain Gary Alexander, Mat Sadler, Kyle McFadzean, Hope Akpan and Nicky Ajose.
That meant Mark Connolly, Joe Walsh, Dannie Bulman, Jonathan Forte and Billy Clarke made way, while Claude Davis didn't recover in time for the game.
Reds: Jones; Hunt, McFadzean, Cooper, Sadler; Adams, Akpan, Simpson, Jones; Alexander, Ajose. Subs: Kuipers, Neilson, Forte, Clarke, Walsh, Connolly, Bulman.
Pompey: Anderson; Harley, Long, Gyepes, Russell; Williamson, Compton, Howard, Thompson; Rodgers, McLeod. Subs: Eastwood, Clifford, Webster, Harris, Walker, Ertl