We profile the high flying Hatters form this season, the history between the two sides, their key man and their Manager in our opposition preview.
Luton Town have been the talk of the league, and that's of no surprise given their form and that they're top of the tree going into Saturday's game at the Checkatrade Stadium.
The Bedfordshire club have won nine, drawn three and lost two so far, and boast a far superior goal difference than anyone else at +22, with the second highest being Notts County's +9.
The Hatters have been scoring at will, 34 in the league to exact, and have put four past Exeter City in their most recent game, seven past Stevenage three days before that and eight past Yeovil Town on the opening day.
Advantage Reds in battle of the towns...
Whilst Luton have the table bragging rights, Crawley have some of their own, as they boast the superior head to head record in the EFL.
The Reds have won four and lost just two when coming up against the Hatters, including a league double in the 2015/16 season.
Last campaign the spoils were shared, with both sides winning their home matches respectively.
Luton claimed a 2-1 victory over the Reds back in February this year, as James Collins' 60th minute opener was overturned by his current employers.
The reverse fixture in September last year finished 2-0 to Crawley, with Collins again finding the net before the result was sealed by Enzio Boldewijn in the dying moments of the game.
The remaining two encounters were cup ties, including a 1-0 Johnstone Paint Trophy win for the Reds in 2014, and an FA Cup First Round win for Luton a year later.
A lot to choose from...
Naturally with a team in such form, it's difficult to pinpoint the true talisman.
Collins is in great goalscoring form with eight goals, and summer signing Luke Berry has found his feet very quickly at Kenilworth Road too.
However it's Danny Hylton who just clinches our 'key man' title.
Like his strike partner, Collins, Hylton too has eight goals so far this campaign and was named in the League Two Team of the Year last season, and also the club's Player of the Season after netting 27 times.
Nathan Jones has been in charge at Luton Town since January last year and has enjoyed a successful stay thus far.
The 44-year old left his role as Brighton First Team Coach to take on his first permanent senior management position, and guided the team away from the threat of relegation and to a respectable 11th place finish.
The following campaign Jones then led his side to a 4th place finish and to the semi-finals of the play-offs, where they would lose 6-5 in dramatic fashion to eventual promotion winners Blackpool.
In his playing days, the former left-back has been on the books at nine different clubs, including two in Spain.
The Welshman's most notable stints were at Southend United, Brighton and Yeovil Town where combined he made over 500 appearances.