The experienced Trevor Kettle from Leicestershire will be in charge on Saturday when Reds take on Exeter City st The People's Pension Stadium.
It will be his first Crawley appointment since October 2018 and the 3-1 defeat at Colchester United.
In the previous season he took charge of three Crawley games, all at home: the 3-1 win over Lincoln City in February 2017, the 2-0 win over Yeovil in September 2017 and the goalless draw with Luton Town the following month.